How calcium makes endocytic receptors attractive.

  title={How calcium makes endocytic receptors attractive.},
  author={Christian Brix Folsted Andersen and S\oren K Moestrup},
  journal={Trends in biochemical sciences},
  volume={39 2},
Nutrients, biological waste-products, toxins, pathogens, and other ligands for endocytosis are typically captured by multidomain receptors with multiligand specificity. Upon internalization, the receptor-ligand complex segregates, followed by lysosomal degradation of the ligand and recycling of the receptor. Endosomal acidification and calcium efflux lead to the essential ligand-receptor affinity switch and separation. Recent data, including crystal structures of receptor-ligand complexes, now… CONTINUE READING
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