How biologically relevant are interaction-based modules in protein networks?

@article{Poyatos2004HowBR,
  title={How biologically relevant are interaction-based modules in protein networks?},
  author={Juan F. Poyatos and Laurence D Hurst},
  journal={Genome Biology},
  year={2004},
  volume={5},
  pages={R93 - R93}
}
By applying a graph-based algorithm to yeast protein-interaction networks we have extracted modular structures and show that they can be validated using information from the phylogenetic conservation of the network components. We show that the module cores, the parts with the highest intramodular connectivity, are biologically relevant components of the networks. These constituents correlate only weakly with other levels of organization. We also discuss how such structures could be used for… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 35 references

MIPS: a database for genomes and protein sequences

Nucleic Acids Research • 2000
View 5 Excerpts
Highly Influenced

Assigning protein functions by comparative genome analysis: protein phylogenetic profiles.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 4 Excerpts
Highly Influenced

Assessing experimentally derived interactions in a small world.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 4 Excerpts
Highly Influenced

Modular organization of cellular networks.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 5 Excerpts
Highly Influenced

Protein complexes and functional modules in molecular networks.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 6 Excerpts
Highly Influenced

Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 1 Excerpt

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