How beta lactam antibiotics enter bacteria : a dialogue with the porins

@inproceedings{James2017HowBL,
  title={How beta lactam antibiotics enter bacteria : a dialogue with the porins},
  author={Chlo{\"e} E. James and Kozhinjampara R Mahendran and Alexander Molitor and Jean-Michel Bolla and Andrey N. Bessonov and Mathias Winterhalter and Jean-Marie Pag{\'e}s},
  year={2017}
}
Background: Multi-drug resistant (MDR) infections have become a major concern in hospitals worldwide. This study investigates membrane translocation, which is the first step required for drug action on internal bacterial targets. b-lactams, a major antibiotic class, use porins to pass through the outer membrane barrier of Gram-negative bacteria. Clinical reports have linked the MDR phenotype to altered membrane permeability including porin modification and efflux pump expression. Methodology… CONTINUE READING