How antidepressants help depression: mechanisms of action and clinical response.

@article{Delgado2004HowAH,
  title={How antidepressants help depression: mechanisms of action and clinical response.},
  author={Pedro L. Delgado},
  journal={The Journal of clinical psychiatry},
  year={2004},
  volume={65 Suppl 4},
  pages={25-30}
}
The monoamine hypothesis of depression suggests that depressive symptoms can be moderated by enhancing monoamine neurotransmission. Targeted neurotransmitters include serotonin and norepinephrine, and a number of medications are available that can selectively enhance the actions of one or both of these substances. Although laboratory tests have validated the pharmacologic effects of these compounds, much less is known about how these effects translate into clinical response. Therapeutic… CONTINUE READING

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