How and when do tumor cells metastasize?

  title={How and when do tumor cells metastasize?},
  author={Marc M. K. Mareel and Frans van Roy and Marc E. Bracke},
  journal={Critical reviews in oncogenesis},
  volume={4 5},
Tumor cells metastasize when they have successfully passed a number of invasion steps. We hypothesize that each step is a microecosystem, the basic elements of which are neoplastic cells, host cells, and extracellular matrix (ECM). We review here molecular pathways with a regulatory function in these microecosystems: homotypic cell-cell adhesion molecules counteracting invasion; complexes of lytic (pro-)enzymes, their receptors and inhibitors regulating focalized breakdown of the ECM; matrix… CONTINUE READING

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