How and Why Does a Fly Turn Its Immune System Off?

  title={How and Why Does a Fly Turn Its Immune System Off?},
  author={David Samuel Schneider},
  journal={PLoS Biology},
  pages={1191 - 1197}
Primer W ith its powerful genetics and rapid generation time, the fruit fl y, Drosophila, provides crucial insights into the evolution and conservation of fundamental immune mechanisms. The best example of molecules discovered in the fl y that are shared in human immunity operate in the Toll signaling pathway, one of fi rst lines of defense against pathogens. Drosophila can also benefi t human health by providing a model for immune systems of arthropod vectors of infectious disease… CONTINUE READING