How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol.

@article{Wolf2006HowAI,
  title={How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol.},
  author={G. Wolf},
  journal={Nutrition reviews},
  year={2006},
  volume={64 6},
  pages={
          295-9
        }
}
  • G. Wolf
  • Published 2006
  • Chemistry, Medicine
  • Nutrition reviews
    • alpha-Tocopherol is the only form of vitamin E in vitamin supplements, whereas gamma-tocopherol is the predominant form of vitamin E in the US diet. gamma-Tocopherol has beneficial properties as an anti-inflammatory and possibly anti-atherogenic and anticancer agent. Excess a-tocopherol taken in supplements causes a reduction of gamma-tocopherol concentration in plasma. The biochemical mechanism of this effect, which is important to human nutrition, has recently been elucidated. 
    View on PubMed
    encognitive.com
    72 Citations
    Highly Influential Citations
    1
    Background Citations
    36
    Results Citations
    3

    Figures and Topics from this paper

    Figures

    Explore Further: Topics Discussed in This Paper

    72 Citations
    Citation Type

    Citation Type

    Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice
    • 18
    • PDF
    Effects of Vitamin E From Supplements and Diet on Colonic α- and γ-tocopherol Concentrations in Persons at Increased Colon Cancer Risk
    • 9
    A MINI-OVERVIEW OF VITAMIN
    • PDF
    Bioavailability of α-tocopherol stereoisomers in lambs depends on dietary doses of all-rac- or RRR-α-tocopheryl acetate.
    • 3
    • PDF
    δ-Tocopherol Is More Active than α- or γ-Tocopherol in Inhibiting Lung Tumorigenesis In Vivo
    • 78
    • PDF
    Supplemental and Highly Elevated Tocopherol Doses Differentially Regulate Allergic Inflammation: Reversibility of α-Tocopherol and γ-Tocopherol’s Effects
    • 50
    • PDF
    Anticancer actions of natural and synthetic vitamin E forms: RRR-alpha-tocopherol blocks the anticancer actions of gamma-tocopherol.
    • 45
    Effects of supplementation with α-tocopherol, ascorbic acid, selenium, or their combination in linseed oil-enriched diets on the oxidative status in broilers
    • 14
    The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study
    • 35
    Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia.
    • 27
    • PDF

    References

    SHOWING 1-10 OF 35 REFERENCES
    gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention.
    • 668
    • Highly Influential
    • PDF
    Supplementation of Diets with α-Tocopherol Reduces Serum Concentrations of γ- and δ-Tocopherol in Humans
    • 160
    • PDF
    Failure of vitamin E in clinical trials: is gamma-tocopherol the answer?
    • 48
    • PDF
    Oral α-Tocopherol Supplements Decrease Plasma γ-Tocopherol Levels in Humans
    • 241
    • Highly Influential
    Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins.
    • 273
    New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine
    • 252
    Cigarette smoke alters human vitamin E requirements.
    • 44
    • PDF
    Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice.
    • 174
    • PDF
    α-Tocopherol modulates Cyp3a expression, increases γ-CEHC production, and limits tissue γ-tocopherol accumulation in mice fed high γ-tocopherol diets
    • 75
    Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients
    • 178