How ageing processes influence cancer
@article{Magalhes2013HowAP, title={How ageing processes influence cancer}, author={J. P. Magalh{\~a}es}, journal={Nature Reviews Cancer}, year={2013}, volume={13}, pages={357-365} }
The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of… CONTINUE READING
Paper Mentions
Blog Post
179 Citations
A Human Tissue-Specific Transcriptomic Analysis Reveals that Ageing Hinders Cancer and Boosts Cellular Senescence
- Biology
- 2019
- 2
- PDF
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
- Biology, Medicine
- Nature communications
- 2016
- 49
Identification of polymorphisms in cancer patients that differentially affect survival with age
- Medicine
- Aging
- 2017
- 7
- PDF
Biologic Mechanisms Linked to Prognosis in Ovarian Cancer that May Be Affected by Aging
- Medicine
- Journal of Cancer
- 2019
- 2
- PDF
The short-lived African turquoise killifish: an emerging experimental model for ageing
- Biology, Medicine
- Disease Models & Mechanisms
- 2016
- 52
- PDF
References
SHOWING 1-10 OF 160 REFERENCES
From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing.
- Medicine
- Experimental cell research
- 2004
- 30
- PDF
From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing.
- Biology
- 2004
- 81
Aging and cancer: issues of basic and clinical science.
- Medicine
- Journal of the National Cancer Institute
- 1997
- 137
- PDF
A review and appraisal of the DNA damage theory of ageing.
- Biology, Medicine
- Mutation research
- 2011
- 165
- PDF
The relationship between aging and carcinogenesis: a critical appraisal.
- Medicine
- Critical reviews in oncology/hematology
- 2003
- 83
- PDF
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
- Medicine, Biology
- Nature communications
- 2010
- 481
- PDF
How does SIRT1 affect metabolism, senescence and cancer?
- Biology, Medicine
- Nature Reviews Cancer
- 2009
- 370
Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery
- Biology, Medicine
- Pharmacological Reviews
- 2012
- 102
- PDF