How ageing processes influence cancer

@article{Magalhes2013HowAP,
  title={How ageing processes influence cancer},
  author={Jo{\~a}o Pedro de Magalh{\~a}es},
  journal={Nature Reviews Cancer},
  year={2013},
  volume={13},
  pages={357-365}
}
The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of… 
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References

SHOWING 1-10 OF 160 REFERENCES
Cancer and ageing: a nexus at several levels
TLDR
New insights into the underlying biological processes of ageing provide a frame of reference for addressing questions about the development or growth of cancer and the benefits and risks of cancer prevention and treatment for the older person.
From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing.
TLDR
In this review, widely used models for studying ageing in cell culture, such as Hayflick's, are interpreted in the context of the human ageing process and mechanisms behind cellular senescence such as telomere disruption and DNA damage are reviewed and their relation to human ageing debated.
The common biology of cancer and ageing
TLDR
The series of key observations that has led to a complex but growing convergence between the understanding of the biology of ageing and the mechanisms that underlie cancer are reviewed.
From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing.
TLDR
In this review, widely used models for studying ageing in cell culture, such as Hayflick's, are interpreted in the context of the human ageing process and mechanisms behind cellular senescence such as telomere disruption and DNA damage are reviewed and their relation to human ageing debated.
Aging and cancer: issues of basic and clinical science.
TLDR
This review has attempted to frame questions regarding cancer and aging from the perspective of biogerontology and geriatric medicine to address the issues of aging at all levels of cancer investigation.
A review and appraisal of the DNA damage theory of ageing.
TLDR
A major role of DNA damage in the modulation of longevity is suggested, possibly through effects on cell dysfunction and loss, although understanding how to modify DNA damage repair and response systems to delay ageing remains a crucial challenge.
The relationship between aging and carcinogenesis: a critical appraisal.
  • V. Anisimov
  • Medicine
    Critical reviews in oncology/hematology
  • 2003
TLDR
Strategies for cancer prevention must include not only measures to minimize exposure to exogenous carcinogenic agents, but also measures to normalize the age-related alterations in internal milieu.
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
TLDR
Results provide direct proof of the anti-ageing activity of Sirt1 in mammals and of its tumour suppression activity in ageing- and metabolic syndrome-associated cancer.
How does SIRT1 affect metabolism, senescence and cancer?
TLDR
It is proposed that the net outcome of the seemingly opposite oncogenic and tumour-suppressive effects of SIRT1 depends on the status of p53.
Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery
TLDR
A broad range of findings in model organisms are reviewed, from environmental to genetic manipulations of aging, with a focus on those with underlying gene-environment interactions with potential for drug discovery and development.
...
1
2
3
4
5
...