How ageing processes influence cancer

@article{Magalhes2013HowAP,
  title={How ageing processes influence cancer},
  author={Jo{\~a}o Pedro de Magalh{\~a}es},
  journal={Nature Reviews Cancer},
  year={2013},
  volume={13},
  pages={357-365}
}
The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of… 
View on Nature
pcwww.liv.ac.uk
194 Citations
Highly Influential Citations
4
Background Citations
101
Methods Citations
1
Results Citations
5

194 Citations

Ageing and cancer: a research gap to fill

TLDR
In this review, a series of research challenges to tackle in the next few years are proposed to better prevent, detect and treat cancer in older patients while preserving their quality of life.

The role of aging in cancer

TLDR
This thematic issue discusses the link between aging and cancer in aspects including somatic mutations, proteostasis, mitochondria, metabolism, senescence, epigenetic regulation, immune regulation, DNA damage, and telomere function.

Age-associated differences in the cancer molecular landscape.

A Human Tissue-Specific Transcriptomic Analysis Reveals that Ageing Hinders Cancer and Boosts Cellular Senescence

TLDR
This work suggests that in most human tissues ageing processes and senescence act in tandem while being detrimental to cancer, and challenges the traditional view concerning the relationship between cancer and ageing.

Ageing, cellular senescence and the impact of diet: an overview

TLDR
The cellular and molecular mechanisms involved in cellular senescence are highlighted and some of the research that is being done about how environmental conditions such as diet can affect the accumulation of senescent cells are discussed.

Age influences on the molecular presentation of tumours

TLDR
It is shown that age shapes the somatic mutational landscape of cancer, with clinical implications, and known cancer driver genes such as CDKN2A and CREBBP are mutated in age-associated frequencies, and these alter the transcriptome and predict for clinical outcomes.

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

TLDR
The analyses suggest that age-associated mutation load and burden double approximately every 8 years, similar to the all-cause mortality doubling time, and offers a mechanism for age being a risk factor for the onset of cancer.

Aging and cancer: Is glucose a mediator between them?

TLDR
The new evidence adds to the concepts that have been being developed starting from mid-1970ies to suggest that age-related shifts in glucose and lipid metabolism increase the risk of cancer and compromise prognoses for cancer patients and to propose antidiabetic biguanides, including metformin, for cancer prevention and as an adjuvant means of cancer treatment aimed at the metabolic rehabilitation of patients.

Eco‐evolutionary perspectives of the dynamic relationships linking senescence and cancer

TLDR
It is argued that cancer itself can promote senescence by notably increasing the amount of resources required for somatic maintenance, and similar evolutionary forces might shape the synchronicity ofsenescence and cancer patterns, which emphasize the tight and complex relationships linking these processes.

Aging and radiation: bad companions

TLDR
The mechanistic interplay between increasing inflammatory response, loss of oxidant/antioxidant equilibrium, ongoing telomere attrition, decline in the DNA damage response efficiency, and deleterious nuclear organization are age‐related cellular changes that trigger a serious threat to genomic integrity.
...

References

SHOWING 1-10 OF 159 REFERENCES

Cancer and ageing: a nexus at several levels

TLDR
New insights into the underlying biological processes of ageing provide a frame of reference for addressing questions about the development or growth of cancer and the benefits and risks of cancer prevention and treatment for the older person.

The common biology of cancer and ageing

TLDR
The series of key observations that has led to a complex but growing convergence between the understanding of the biology of ageing and the mechanisms that underlie cancer are reviewed.

From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing.

TLDR
In this review, widely used models for studying ageing in cell culture, such as Hayflick's, are interpreted in the context of the human ageing process and mechanisms behind cellular senescence such as telomere disruption and DNA damage are reviewed and their relation to human ageing debated.

From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing.

Aging and cancer: issues of basic and clinical science.

TLDR
This review has attempted to frame questions regarding cancer and aging from the perspective of biogerontology and geriatric medicine to address the issues of aging at all levels of cancer investigation.

A review and appraisal of the DNA damage theory of ageing.

The relationship between aging and carcinogenesis: a critical appraisal.

  • V. Anisimov
  • Medicine, Biology
    Critical reviews in oncology/hematology
  • 2003

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

TLDR
Results provide direct proof of the anti-ageing activity of Sirt1 in mammals and of its tumour suppression activity in ageing- and metabolic syndrome-associated cancer.

How does SIRT1 affect metabolism, senescence and cancer?

TLDR
It is proposed that the net outcome of the seemingly opposite oncogenic and tumour-suppressive effects of SIRT1 depends on the status of p53.

Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery

TLDR
A broad range of findings in model organisms are reviewed, from environmental to genetic manipulations of aging, with a focus on those with underlying gene-environment interactions with potential for drug discovery and development.
...