How ageing processes influence cancer

@article{Magalhes2013HowAP,
  title={How ageing processes influence cancer},
  author={Jo{\~a}o Pedro de Magalh{\~a}es},
  journal={Nature Reviews Cancer},
  year={2013},
  volume={13},
  pages={357-365}
}
The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of… 
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193 Citations
Highly Influential Citations
5
Background Citations
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193 Citations

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This is the first systematic analysis that combines a large longitudinal data set with a targeted candidate gene approach to examine the effect of genetic variation on survival as a function of age in cancer patients, demonstrating that there are ageing-related genetic elements that differentially affect mortality incancer patients in an age-dependent manner.
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