How a radial glial cell decides to become a multiciliated ependymal cell

@article{Kyrousi2017HowAR,
  title={How a radial glial cell decides to become a multiciliated ependymal cell},
  author={Christina Kyrousi and Zoi Lygerou and Stavros L. Taraviras},
  journal={Glia},
  year={2017},
  volume={65}
}
The V‐SVZ adult neurogenic niche is located in the wall of the lateral ventricles and contains neural stem cells, with self‐renewing and differentiating ability and postmitotic multiciliated ependymal cells, an important structural and trophic component of the niche. The niche is established at postnatal stages from a subpopulation of radial glial cells, determined during embryogenesis. Radial glial cells constitute a heterogeneous population, which give rise, in addition to niche cellular… 
GemC1 is a critical switch for neural stem cell generation in the postnatal brain
TLDR
It is shown here that GemC1, encoding Geminin coiled‐coil domain‐containing protein 1, is associated with congenital hydrocephalus in humans and mice and regulates the balance between NSC generation and ependymal cell differentiation, with implications for the pathogenesis of human congenital Hydrocephalus.
BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors
TLDR
The results implicate BMP signaling in suppression of ependymal differentiation from NPCs through regulation of Gemc1 and Mcidas expression during embryonic and early-postnatal stages of mouse telencephalic development.
The role of lipids in ependymal development and the modulation of adult neural stem cell function during aging and disease.
TLDR
The developmental origins of the rodent V-SVZ neurogenic niche are discussed, research which has implicated a role for lipids in the physiology of this part of the brain is highlighted, and new research is discussed which has suggested that alterations to lipid biology could contribute to ependymal cell dysfunction in aging and disease.
3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots
TLDR
This review intends to update the most recent information regarding the SVZ niche physiology and the diverse biofabrication approaches that have been used to develop suitable microenvironments ex vivo that mimic the NSC niche physiology.
Ontogeny of adult neural stem cells in the mammalian brain.
TLDR
A better understanding of the developmental process that enables NSCs to persist beyond development will provide insight into factors that determine the size and properties of the adult NSC pool and thus the capacity for life-long neurogenesis in the adult mammalian brain.
Bone Morphogenetic Proteins Inhibit Ciliogenesis of Ependymal Cells in Vitro.
TLDR
Investigation of the effects of two BMPs, BMP2 and BMP4, on the ependymal differentiation of the primary cultured cells prepared from the neonatal mouse brain suggests that inhibition of the BMP signaling pathway might be essential for ciliogenesis during the ependedymal cell differentiation in vivo.
Transcriptional regulation of multiciliated cell differentiation.
TLDR
This review will focus on providing an overview of the transcriptional regulation of MCCs and its connection to key processes, in addition to highlighting exciting recent developments and open questions in the field.
Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases
TLDR
It is suggested that the potential role of Wnt/β-catenin signaling might lead to new therapeutic strategies for neurological diseases, including, but not limited to, spinal cord injury, Alzheimer’s disease, Parkinson's disease, and depression.
GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73
TLDR
It is shown that the geminin coiled-coil domain-containing protein 1 GemC1 regulates the transcriptional activation of p73, a transcription factor central to multiciliogenesis, and modifies the chromatin organization of the p73 locus in order to generate multiciliated cells.
Ependymal cells in the spinal cord as neuronal progenitors.
TLDR
The main phenotypical characteristics of ependymal cells from spinal cord and the opportunities offered for spinal cord injury therapeutic application are described.
...
1
2
...

References

SHOWING 1-10 OF 115 REFERENCES
Mcidas and GemC1/Lynkeas specify embryonic radial glial cells
TLDR
It is proposed that Mcidas and GemC1/Lynkeas are key components of the molecular cascade that promotes radial glial cells fate commitment toward multiciliated ependymal cell lineage operating upstream of c-Myb and FoxJ1.
p73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture
TLDR
The data reveal a completely new function of p73, independent of p53, in the neurogenic architecture of the SVZ of rodent brain and in the establishment of ependymal planar cell polarity with important implications in neurogenesis.
Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.
TLDR
It is demonstrated that Gli3R expressed in radial glia temporally regulates gp130/STAT3 signaling at the transcriptional level to suppress glial characteristics in differentiating ependymal cells and maintains the proper level of Numb in ependyal cells to allow localization of cell adhesion molecules such as vascular cellAdhesion molecule (VCAM) and E-cadherin.
FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain
TLDR
It is suggested that time- and cell-specific expression of FoxJ1 in the brain acts on an array of target genes to regulate the differentiation of ependymal cells and a small subset of astrocytes in the adult stem cell niche.
Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis
TLDR
The results indicate that ependymal cells are born in the embryonic and early postnatal brain and that they do not divide after differentiation, which strongly suggests that these cells do not function as neural stem cells in the adult.
The glial nature of embryonic and adult neural stem cells.
TLDR
The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
Pigment epithelium–derived factor is a niche signal for neural stem cell renewal
TLDR
It is shown that pigment epithelium–derived factor (PEDF) is secreted by components of the murine SVZ and promotes self-renewal of adult NSCs in vitro and provides evidence for a role for PEDF protein in NSC maintenance.
Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche
TLDR
In the adult mouse brain, Mcidas and GemC1 act upstream of the transcriptional regulators Foxj1 and c-Myb to promote differentiation of ependymal cells from radial glia.
Lake-Front Property: A Unique Germinal Niche by the Lateral Ventricles of the Adult Brain
TLDR
The integration of emerging molecular and anatomical clues forecasts an exciting new understanding of how the germ of youth is actively maintained in the adult brain.
Mind Bomb 1-Expressing Intermediate Progenitors Generate Notch Signaling to Maintain Radial Glial Cells
TLDR
It is reported that conditional inactivation of mind bomb-1 (mib1) in mice using the nestin and hGFAP promoters resulted in complete loss of Notch activation, which leads to depletion of RGCs, and premature differentiation into intermediate progenitors (IPs) and finally neurons, which were reverted by the introduction of active Notch1.
...
1
2
3
4
5
...