How a neutral evolutionary ratchet can build cellular complexity

@article{Luke2011HowAN,
  title={How a neutral evolutionary ratchet can build cellular complexity},
  author={Julius Luke{\vs} and John M. Archibald and Patrick J. Keeling and W. Ford Doolittle and Michael W. Gray},
  journal={IUBMB Life},
  year={2011},
  volume={63}
}
Complex cellular machines and processes are commonly believed to be products of selection, and it is typically understood to be the job of evolutionary biologists to show how selective advantage can account for each step in their origin and subsequent growth in complexity. Here, we describe how complex machines might instead evolve in the absence of positive selection through a process of “presuppression,” first termed constructive neutral evolution (CNE) more than a decade ago. If an… Expand
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