How a damaged blood vessel wall contibutes to thrombosis and hypertenasion.

  title={How a damaged blood vessel wall contibutes to thrombosis and hypertenasion.},
  author={Andrew D. Blann},
  journal={Pathophysiology of haemostasis and thrombosis},
  volume={33 5-6},
  • Andrew D. Blann
  • Published 2003 in Pathophysiology of haemostasis and thrombosis
In order to maintain an anticoagulant nature, the healthy endothelium secretes factors such as tissue plasminogen activator, ADPase, and expresses membrane thrombomodulin. However, when damaged, it releases increased amounts of pro-coagulants such as von Willebrand factor. Similarly, the healthy endothelium uses nitric oxide, prostacyclin and other molecules to help maintain normal blood pressure, and these molecules also inhibit platelet activity. But a dysfunctional endothelium fails to… CONTINUE READING


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