How a G protein binds a membrane.

@article{Zhang2004HowAG,
  title={How a G protein binds a membrane.},
  author={Zhixian Zhang and Thomas J. Melia and Feng He and Ching Yuan and Amy McGough and Michael F. Schmid and Theodore G Wensel},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 32},
  pages={33937-45}
}
Heterotrimeric G proteins interact with receptors and effectors at the membrane-cytoplasm interface. Structures of soluble forms have not revealed how they interact with membranes. We have used electron crystallography to determine the structure in ice of a helical array of the photoreceptor G protein, transducin, bound to the surface of a tubular lipid bilayer. The protein binds to the membrane with a very small area of contact, restricted to two points, between the surface of the protein and… CONTINUE READING

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Biochemistry 31, 9502–9512 Transducin-lipid Helical Tubules

  • J. A. Malinski, T. G. Wensel
  • H A M -T M C Lrary on July 3,
  • 1992

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