How a Circadian Clock Adapts to Seasonal Decreases in Temperature and Day Length

@article{Majercak1999HowAC,
  title={How a Circadian Clock Adapts to Seasonal Decreases in Temperature and Day Length},
  author={J. Majercak and D. Sidote and P. Hardin and I. Edery},
  journal={Neuron},
  year={1999},
  volume={24},
  pages={219-230}
}
We show that a thermosensitive splicing event in the 3' untranslated region of the mRNA from the period (per) gene plays an important role in how a circadian clock in Drosophila adapts to seasonally cold days (low temperatures and short day lengths). The enhanced splicing of this intron at low temperatures advances the steady state phases of the per mRNA and protein cycles, events that significantly contribute to the preferential daytime activity of flies on cold days. Because the accumulation… Expand
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