How TGF-beta and PAX3 regulate suntanning.

  title={How TGF-beta and PAX3 regulate suntanning.},
  author={Mary R Loeken},
  journal={Pigment cell & melanoma research},
  volume={22 2},
The processes by which ultraviolet (UV) radiation induces melanin synthesis to induce a suntan is complex, involving signaling between keratinocytes and melanocytes. Although much is known about the enzymes involved in melanin production, there have been gaps in understanding how key transcriptional regulators of melanogenesis are regulated. A recent study by Cui and colleagues elucidated how expression of PAX3, a gene that encodes a transcription factor that is involved in melanocyte… CONTINUE READING