How T cells use LFA-1 to attach and migrate.

  title={How T cells use LFA-1 to attach and migrate.},
  author={Nancy Hogg and Andrew Smith and Alison McDowall and Katherine Giles and Paula Stanley and Melanie Laschinger and Robert Henderson},
  journal={Immunology letters},
  volume={92 1-2},
The T lymphocyte (or T cell) has classically been perceived to be a passive circular cell attaching to other cells or fibrils of the extracellular matrix when its integrins become activated. We now understand that the modus operandi of the T cell is migration. These cells are proving to be impressively fast migrators, clocking up basal speeds of approximately 10-15 microm/min which makes them amongst the fastest movers recorded to date. Therefore, migration is the business of the T cell and in… CONTINUE READING

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