How Should We Be Treating Children with Congenital Hypothyroidism?

@article{Lafranchi2007HowSW,
  title={How Should We Be Treating Children with Congenital Hypothyroidism?},
  author={Stephen H Lafranchi and Juliana Austin},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  year={2007},
  volume={20},
  pages={559 - 578}
}
Early detection by newborn screening and appropriate L-thyroxine treatment leads to normal or near-normal neurocognitive outcome in infants with congenital hypothyroidism. Many newborns with congenital hypothyroidism have some residual thyroid hormone production, and even in those with athyreosis, transplacental passage of maternal thyroid hormone offers some protection for a time. Given the serum T4 half-life of 6 days, the neonatal T4 level will fall and disappear over the first 2-3 weeks of… 

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TLDR
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TLDR
Efforts are ongoing to establish the optimal therapy that leads to maximum potential for normal development for infants with congenital hypothyroidism, as well as to maintain frequent evaluations of total Thyroxine or free thyroxine in the upper half of the reference range during the first 3 years of life.
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TLDR
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TLDR
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TLDR
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A controlled longitudinal prospective study is reported of physical and neuropsychological progress up to 12 years in 152 children with congenital hypothyroidism (CH), detected by newborn screening
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