How S4 Segments Move Charge. Let Me Count the Ways

  title={How S4 Segments Move Charge. Let Me Count the Ways},
  author={Richard Horn},
  journal={The Journal of General Physiology},
  pages={1 - 4}
  • Richard Horn
  • Published 2004 in The Journal of general physiology
The four " charged particles " predicted to underlie the voltage-dependent gating of some ion channels (Hodgkin and Huxley, 1952) are now known to be the four S4 segments, putative ␣-helices in which every third residue (in many, but not all, S4 segments) is either arginine or lysine. These charged structures must reside at least partly within the membrane electric field and move some of their positive charges across this electric field in response to changes of membrane potential. There are… CONTINUE READING
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