How Reliable Is Ki-67 Immunohistochemistry in Grade 2 Breast Carcinomas? A QA Study of the Swiss Working Group of Breast- and Gynecopathologists

@inproceedings{Varga2012HowRI,
  title={How Reliable Is Ki-67 Immunohistochemistry in Grade 2 Breast Carcinomas? A QA Study of the Swiss Working Group of Breast- and Gynecopathologists},
  author={Zsuzsanna Varga and Joachim Diebold and Corina Dommann-Scherrer and Harald Frick and Daniela Kaup and Aurelia Noske and Ellen Christina Obermann and Christian Ohlschlegel and Barbara -Christina Padberg and Christiane Rakozy and Sara Sancho Oliver and Sylviane Schobinger-Cl{\'e}ment and Heide Schreiber-Facklam and Gamal A. M. Singer and C. A. Luna Tapia and Urs Wagner and Mauro Giuseppe Mastropasqua and Guiseppe Viale and H. A. Lehr},
  booktitle={PloS one},
  year={2012}
}
UNLABELLED Adjuvant chemotherapy decisions in breast cancer are increasingly based on the pathologist's assessment of tumor proliferation. The Swiss Working Group of Gyneco- and Breast Pathologists has surveyed inter- and intraobserver consistency of Ki-67-based proliferative fraction in breast carcinomas. METHODS Five pathologists evaluated MIB-1-labeling index (LI) in ten breast carcinomas (G1, G2, G3) by counting and eyeballing. In the same way, 15 pathologists all over Switzerland then… CONTINUE READING

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