How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?

@article{Chan2004HowMM,
  title={How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?},
  author={Wan Chan and W. Y. Siu and A. Lau and R. Poon},
  journal={Molecular and Cellular Biology},
  year={2004},
  volume={24},
  pages={3536 - 3551}
}
ABSTRACT The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand, the p53-related p63 and p73 genes are rarely mutated, but many cell types express natural variants lacking the N-terminal transactivation domain (NΔ). Compelling evidence indicates that both the DNA binding-defective and NΔ mutants can impair the function of wild-type p53 in a dominant-negative… Expand
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