How MDMA's Pharmacology and Pharmacokinetics Drive Desired Effects and Harms

@article{White2014HowMP,
  title={How MDMA's Pharmacology and Pharmacokinetics Drive Desired Effects and Harms},
  author={C. Michael White},
  journal={The Journal of Clinical Pharmacology},
  year={2014},
  volume={54}
}
  • C. Michael White
  • Published 2014
  • Medicine
  • The Journal of Clinical Pharmacology
    • 3,4‐Methylenedioxymethamphetamine (MDMA) is an agent of abuse that has been used by over 16 million Americans. Increased energy, elevated mood, bonding with others, and psychedelic effects are desired effects while liver damage, extended depressed mood, sexual assault, rhabdomyolysis, serotonin syndrome, multiorgan failure, cardiovascular events, arrhythmias, and death are possible adverse effects. These desirable and adverse effects of MDMA are extensions of its fascinating pharmacologic and… CONTINUE READING
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    References

    SHOWING 1-10 OF 37 REFERENCES
    Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics
    • 142
    • PDF
    Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug–drug interactions
    • 39
    • Highly Influential
    Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2 h apart
    • 33
    • PDF
    Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management.
    • 231
    • Highly Influential
    • PDF
    Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview
    • 247
    • Highly Influential
    Cortisol and 3,4-Methylenedioxymethamphetamine: Neurohormonal Aspects of Bioenergetic Stress in Ecstasy Users
    • A. Parrott
    • Psychology, Medicine
    • Neuropsychobiology
    • 2009
    • 63
    Duloxetine Inhibits Effects of MDMA (“Ecstasy") In Vitro and in Humans in a Randomized Placebo-Controlled Laboratory Study
    • 119
    • Highly Influential
    • PDF
    Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
    • 172
    • PDF
    Pharmacogenetic studies of change in cortisol on ecstasy (MDMA) consumption
    • 35
    Interaction of 3,4‐Methylenedioxymethamphetamine and Methamphetamine During Metabolism by In Vitro Human Metabolic Enzymes and in Rats *
    • 13