How I treat CML blast crisis.

@article{Hehlmann2012HowIT,
  title={How I treat CML blast crisis.},
  author={R{\"u}diger Hehlmann},
  journal={Blood},
  year={2012},
  volume={120 4},
  pages={737-47}
}
Blast crisis (BC) remains the major challenge in the management of chronic myeloid leukemia (CML). It is now generally accepted that BC is the consequence of continued BCR-ABL activity leading to genetic instability, DNA damage, and impaired DNA repair. Most patients with BC carry multiple mutations, and up to 80% show additional chromosomal aberrations in a nonrandom pattern. Treatment with tyrosine kinase inhibitors has improved survival in BC modestly, but most long-term survivors are those… CONTINUE READING
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