How Fast-Folding Proteins Fold

@article{LindorffLarsen2011HowFP,
  title={How Fast-Folding Proteins Fold},
  author={Kresten Lindorff-Larsen and S. Piana and R. Dror and D. Shaw},
  journal={Science},
  year={2011},
  volume={334},
  pages={517 - 520}
}
  • Kresten Lindorff-Larsen, S. Piana, +1 author D. Shaw
  • Published 2011
  • Chemistry, Medicine
  • Science
  • Millisecond-scale molecular dynamics simulations of 12 proteins reveal a set of common principles for protein folding. An outstanding challenge in the field of molecular biology has been to understand the process by which proteins fold into their characteristic three-dimensional structures. Here, we report the results of atomic-level molecular dynamics simulations, over periods ranging between 100 μs and 1 ms, that reveal a set of common principles underlying the folding of 12 structurally… CONTINUE READING
    1,228 Citations

    Topics from this paper

    Atomistic description of the folding of a dimeric protein.
    • 39
    Native contacts determine protein folding mechanisms in atomistic simulations
    • 275
    • PDF
    Atomic-level description of ubiquitin folding
    • 234
    • PDF
    Computational study of the biophysics of protein conformational switching
    • PDF
    Accelerated molecular dynamics simulations of protein folding
    • 65
    Revealing the global map of protein folding space by large-scale simulations.
    • 4
    Slow unfolded-state structuring in Acyl-CoA binding protein folding revealed by simulation and experiment.
    • 117

    References

    SHOWING 1-10 OF 64 REFERENCES
    Atomic-Level Characterization of the Structural Dynamics of Proteins
    • 1,318
    • PDF
    Protein folding and the organization of the protein topology universe.
    • 91
    • PDF
    Protein folding and misfolding: mechanism and principles.
    • 177
    • PDF
    Ultrafast folding of α3D: A de novo designed three-helix bundle protein
    • Yongjin Zhu, D. Alonso, +6 authors F. Gai
    • Chemistry
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2003
    • 128
    • PDF
    Sub-microsecond protein folding.
    • 199
    • PDF
    Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications.
    • A. Fersht
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1995
    • 404
    • PDF
    Small proteins fold through transition states with native-like topologies.
    • 30
    • PDF