How Fast-Folding Proteins Fold

@article{LindorffLarsen2011HowFP,
  title={How Fast-Folding Proteins Fold},
  author={Kresten Lindorff-Larsen and Stefano Piana and Ron O. Dror and David E. Shaw},
  journal={Science},
  year={2011},
  volume={334},
  pages={517 - 520}
}
Millisecond-scale molecular dynamics simulations of 12 proteins reveal a set of common principles for protein folding. An outstanding challenge in the field of molecular biology has been to understand the process by which proteins fold into their characteristic three-dimensional structures. Here, we report the results of atomic-level molecular dynamics simulations, over periods ranging between 100 μs and 1 ms, that reveal a set of common principles underlying the folding of 12 structurally… 
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