How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

@article{Mebratu2009HowEA,
  title={How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?},
  author={Yohannes A. Mebratu and Yohannes Tesfaigzi},
  journal={Cell cycle},
  year={2009},
  volume={8 8},
  pages={1168-75}
}
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase super family that can mediate cell proliferation and apoptosis. The Ras-Raf-MEK-ERK signaling cascade controlling cell proliferation has been well studied but the mechanisms involved in ERK1/2-mediated cell death are largely unknown. This review focuses on recent papers that define ERK1/2 translocation to the nucleus and the proteins involved in the cytosolic retention of… CONTINUE READING

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