How Does Genetics Influence the Efficacy and Safety of Antiarrhythmic Drugs?

Abstract

Recent progress in genomic sequencing has begun to elucidate the basic mechanisms for several adverse responses, as well as the clinical efficacy, for antiarrhythmic drugs. DNA variants in drug metabolizing enzymes have been implicated in excessive drug accumulation, and genetic variability in drug targets can identify individuals at increased risk for… (More)
DOI: 10.1016/j.ccep.2010.06.004

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