How Do Gangliosides Regulate RTKs Signaling?

  title={How Do Gangliosides Regulate RTKs Signaling?},
  author={Sylvain Julien and Marie Bobowski and Agata Steenackers and Xuefen Le Bourhis and Philippe Delannoy},
Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of gangliosides in the regulation of signal transduction has been reported in many cases and in a large number of cell types. In this review, we summarize the current knowledge on the biosynthesis of… CONTINUE READING
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