How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis.

Abstract

Mammalian cells treated with ultraviolet (UV) light provide one of the best-known experimental systems for depicting the biological consequences of DNA damage. UV irradiation induces the formation of DNA photoproducts, mainly cyclobutane pyrimidine dimers (CPDs) and (6-4) pyrimidine-pyrimidone photoproducts [(6-4)PPs], that drastically impairs DNA… (More)
DOI: 10.1016/j.mrrev.2008.09.001

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