How Cytokine Networks Fuel Inflammation: Interleukin-17 and a tale of two autoimmune diseases

@article{Baeten2013HowCN,
  title={How Cytokine Networks Fuel Inflammation: Interleukin-17 and a tale of two autoimmune diseases},
  author={D. Baeten and Vijay K Kuchroo},
  journal={Nature Medicine},
  year={2013},
  volume={19},
  pages={824-825}
}
During the last decade, studies using animal models of autoimmunity have led to the identification of a molecularly and functionally distinct T cell subset called T helper type 17 (TH17) cells that produce a signature cytokine, interleukin-17A (IL-17A), which is defined as a key mediator of chronic tissue inflammation1,2. Although the proinflammatory function of this cytokine was originally described in human rheumatoid arthritis synovial fibroblasts in vitro, it was the key role of IL-23… CONTINUE READING
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