How Conformational Dynamics Influences the Protein Search for Targets on DNA

  title={How Conformational Dynamics Influences the Protein Search for Targets on DNA},
  author={Maria P. Kochugaeva and Alexey A. Shvets and Anatoly B Kolomeisky},
Protein search and association to specific sequences on DNA is a starting point for all fundamental biological processes. It has been intensively studied in recent years by a variety of experimental and theoretical methods. However, many features of these complex biological phenomena are still not resolved at the molecular level. Experiments indicate that proteins can be bound nonspecifically to DNA in multiple configurations. But the role of conformational fluctuations in the protein search… CONTINUE READING

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