How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial

@article{Laine2009HowCI,
  title={How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial},
  author={Loren Laine and Lawrence Goldkind and Sean P. Curtis and Laurine G Connors and Zhang Yanqiong and Christoper P Cannon},
  journal={The American Journal of Gastroenterology},
  year={2009},
  volume={104},
  pages={356-362}
}
OBJECTIVES:Few data are available from prospective trials to define the hepatotoxicity of diclofenac, the most widely prescribed non-steroidal anti-inflammatory drug (NSAID) in the world. We determined the rate of laboratory and clinical adverse hepatic effects in a large double-blind trial of diclofenac.METHODS:Patients ≥50 years with rheumatoid arthritis or osteoarthritis were randomly assigned to diclofenac (150 mg daily) or etoricoxib (60 or 90 mg daily). Patients with hepatic disease or… CONTINUE READING

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