How COVID vaccines shaped 2021 in eight powerful charts.

@article{Mallapaty2021HowCV,
  title={How COVID vaccines shaped 2021 in eight powerful charts.},
  author={Smriti Mallapaty and Ewen Callaway and Max Kozlov and Heidi Ledford and John W. Pickrell and Richard van Noorden},
  journal={Nature},
  year={2021}
}
The extraordinary vaccination of more than four billion people, and the lack of access for many others, were major forces this year - while Omicron's arrival complicated things further. The extraordinary vaccination of more than four billion people, and the lack of access for many others, were major forces this year - while Omicron's arrival complicated things further. 
The Coronavirus pandemic – 2022: Viruses, variants & vaccines
COVID-19: vaccines, efficacy and effects on variants
TLDR
Three leading strategies of vaccine development against coronavirus disease 2019 (COVID- 19): mRNA vaccines, adenoviral vector vaccines and recombinant nanoparticles are reviewed and the evidence for the effectiveness of the vaccines against those five VoC is explored.
Vaccination and three non-pharmaceutical interventions determine the dynamics of COVID-19 in the US
TLDR
A new analytical framework is developed that treats COVID-19 as a feedback control system with the NPIs and vaccination as the controllers and a computational model that maps human social behaviors into input signals to effectively predict the epidemic spreading in 381 Metropolitan statistical areas (MSAs) in the US.
Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil
TLDR
A test-negative case–control analysis of data from Brazil shows that vaccine effectiveness against SARS-CoV-2 infection and severe COVID-19 outcomes declines after two doses of CoronaVac but increases after a booster dose of the BNT162b2 vaccine.
Autoimmune post-COVID vaccine syndromes: does the spectrum of autoimmune/inflammatory syndrome expand?
TLDR
Rheumatologists must be alert to the development of these autoimmune syndromes, and investigate the relationship between autoimmune/inflammatory symptoms and vaccination time, and assess their therapeutic response.
The Remarkable Evolutionary Plasticity of Coronaviruses by Mutation and Recombination: Insights for the COVID-19 Pandemic and the Future Evolutionary Paths of SARS-CoV-2
TLDR
A review of studies over the last two years that reveal the impact of point mutations, insertions/deletions, and intratypic/intertypic homologous and non-homologous recombination events on the evolution of CoVs, and whether the next generations of CoV vaccines should be directed against other CoV proteins in addition to or instead of spike.
Emerging and Re-Emerging Infectious Diseases: Humankind’s Companions and Competitors
TLDR
Infectious disease outbreaks had a significant impact on shaping the societies and cultures throughout human history and continue to do so today.
Differences between Omicron SARS-CoV-2 RBD and other variants in their ability to interact with cell receptors and monoclonal antibodies
TLDR
This work aims to expand the knowledge about the SARS-CoV-2 receptor-binding domain (RBD) interactions with cell receptors and monoclonal antibodies (mAbs) and found these mAbs and especially their combination are amenable to experimentation and clinical trials because of their high binding affinities and neutralization potential for current known virus mutations and a universal coronavirus.
Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens
TLDR
Although the ChAdOx1 vaccine was inferior to mRNA and Ad26.COV2.S in several respects, biochemical and structural analyses revealed enrichment in a subgroup of memory B cell neutralizing antibodies with distinct RBD-binding properties resulting in remarkable potency and breadth.
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