How B cells capture, process and present antigens: a crucial role for cell polarity

  title={How B cells capture, process and present antigens: a crucial role for cell polarity},
  author={Mar{\'i}a Isabel Yuseff and Paolo Pierobon and Anne Reversat and Ana-Mar{\'i}a Lennon-Dum{\'e}nil},
  journal={Nature Reviews Immunology},
B cells are key components of the adaptive immune response. Their differentiation into either specific memory B cells or antibody-secreting plasma cells is a consequence of activation steps that involve the processing and presentation of antigens. The engagement of B cell receptors by surface-tethered antigens leads to the formation of an immunological synapse that coordinates cell signalling events and that promotes antigen uptake for presentation on MHC class II molecules. In this Review, we… 

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