Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.

@article{Eng2015HousingTS,
  title={Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.},
  author={Jason W-L Eng and Chelsey B. Reed and Kathleen M Kokolus and Rosemarie F Pitoniak and Adam Utley and Mark J. Bucsek and Wen Wee Ma and Elizabeth A. Repasky and Bonnie L. Hylander},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          6426
        }
}
Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is significantly increased when mice are housed at a thermoneutral ambient temperature of 30 °C compared with the standard temperature of 22 °C. Further, we find that baseline levels of norepinephrine as well as the levels of several anti-apoptotic molecules are elevated in tumours from mice housed at… CONTINUE READING
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