House dust mite extract downregulates C/EBPα in asthmatic bronchial smooth muscle cells.

@article{Miglino2011HouseDM,
  title={House dust mite extract downregulates C/EBPα in asthmatic bronchial smooth muscle cells.},
  author={Nicola Miglino and Michael Roth and Michael Tamm and Peter Borger},
  journal={The European respiratory journal},
  year={2011},
  volume={38 1},
  pages={50-8}
}
Reduced translation of CEBPA mRNA has been associated with increased proliferation of bronchial smooth muscle (BSM) cells of asthma patients. Here, we assessed the effect of house dust mite (HDM) extracts on the cell proliferation ([(3)H]-thymidine incorporation), inflammation (interleukin (IL)-6 release) and upstream translation regulatory proteins of CCAAT/enhancer-binding protein (C/EBP)α in human BSM cells of healthy controls and asthmatic patients. HDM extract significantly increased IL-6… CONTINUE READING
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