Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

  title={Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells},
  author={Ryan Lister and Mattia Pelizzola and Yasuyuki S. Kida and R. David Hawkins and Joseph R Nery and Gary Chung Hon and Jessica Antosiewicz-Bourget and Ronan C. O’Malley and Rosa Castanon and Sarit A. Klugman and Michael Downes and Ruth T Yu and Ron Stewart and Bing Ren and James A. Thomson and Ronald M Evans and Joseph R. Ecker},
Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine and studies of disease and development. Somatic cell reprogramming involves epigenomic reconfiguration, conferring iPSCs with characteristics similar to embryonic stem (ES) cells. However, it remains unknown how complete the reestablishment of ES-cell-like DNA methylation patterns is throughout the genome. Here we report the first whole-genome profiles of DNA methylation at single-base resolution in five… CONTINUE READING
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