Hot spots in β-catenin for interactions with LEF-1, conductin and APC

@article{Kries2000HotSI,
  title={Hot spots in $\beta$-catenin for interactions with LEF-1, conductin and APC},
  author={Jens P. von Kries and Georgia Winbeck and Christian Asbrand and Thomas Schwarz‐Romond and Natalia Sochnikova and Andrea Dell'Oro and J{\"u}rgen Behrens and Walter Birchmeier},
  journal={Nature Structural Biology},
  year={2000},
  volume={7},
  pages={800-807}
}
Interactions between β-catenin and LEF-1/TCF, APC and conductin/axin are essential for wnt-controlled stabilization of β-catenin and transcriptional activation. The wnt signal transduction pathway is important in both embryonic development and tumor progression. We identify here amino acid residues in β-catenin that distinctly affect its binding to LEF-1/TCF, APC and conductin. These residues form separate surface clusters, termed hot spots, along the armadillo superhelix of β-catenin. We also… 

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