Hot spots—A review of the protein–protein interface determinant amino‐acid residues

@article{Moreira2007HotSR,
  title={Hot spots—A review of the protein–protein interface determinant amino‐acid residues},
  author={Irina Sousa Moreira and Pedro Alexandrino Fernandes and Maria Jo{\~a}o Ramos},
  journal={Proteins: Structure},
  year={2007},
  volume={68}
}
Proteins tendency to bind to one another in a highly specific manner forming stable complexes is fundamental to all biological processes. A better understanding of complex formation has many practical applications, which include the rational design of new therapeutic agents, and the analysis of metabolic and signal transduction networks. Alanine‐scanning mutagenesis made possible the detection of the functional epitopes, and demonstrated that most of the protein–protein binding energy is… Expand
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