Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases

Abstract

Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase-quinolone complexes. A careful statistical analysis of preferred bases was performed on a large number (>400) of… (More)

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Richter2007HotspotCO, title={Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases}, author={Sara N Richter and Giulia Giaretta and Valentina Comuzzi and Elisabetta Di Leo and Lesley A. Mitchenall and L Mark Fisher and Anthony Maxwell and M Elisabetta Palumbo}, booktitle={Nucleic acids research}, year={2007} }