Hot spot-based design of small-molecule inhibitors for protein-protein interactions.


Protein-protein interactions (PPIs) are important targets for the development of chemical probes and therapeutic agents. From the initial discovery of the existence of hot spots at PPI interfaces, it has been proposed that hot spots might provide the key for developing small-molecule PPI inhibitors. However, there has been no review on the ways in which the… (More)
DOI: 10.1016/j.bmcl.2014.03.095


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