Host-specificity of uropathogenic Escherichia coli depends on differences in binding specificity to Gal alpha 1-4Gal-containing isoreceptors.

@article{Strmberg1990HostspecificityOU,
  title={Host-specificity of uropathogenic Escherichia coli depends on differences in binding specificity to Gal alpha 1-4Gal-containing isoreceptors.},
  author={Nicklas Str{\"o}mberg and Brodin Marklund and B Lund and Dag Ilver and Anja M. Hamers and Wim Gaastra and K. A. Karlsson and Staffan J. Normark},
  journal={The EMBO journal},
  year={1990},
  volume={9 6},
  pages={2001-10}
}
Four G adhesins, cloned from uropathogenic Escherichia coli strains, were examined for binding to glycolipids and various eukaryotic cells. PapGAD110 and PapGIA2 showed virtually identical binding patterns to Gal alpha 1-4Gal-containing glycolipids, while PapGJ96 differed slightly and PrsGJ96 markedly with respect to the effect of neighbouring groups on the binding. Their hemagglutination patterns confirmed the existence of three receptor-binding specificities. While the PapG adhesins bound to… CONTINUE READING

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