Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection.

@article{Roberts2006HostRA,
  title={Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection.},
  author={Eleanor S Roberts and Salvador Huitr{\'o}n-Res{\'e}ndiz and Michael A Taffe and Maria Cecilia Garibaldi Marcondes and Claudia T. Flynn and Caroline M. S. Lanigan and Jennifer A. Hammond and Steven Robert Head and Steven J. Henriksen and Howard S. Fox},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 17},
  pages={4577-85}
}
CNS abnormalities can be detected during chronic human immunodeficiency virus (HIV) infection, before the development of opportunistic infections or other sequelae of immunodeficiency. However, although end-stage dementia caused by HIV has been linked to the presence of infected and activated macrophages and microglia in the brain, the nature of the changes resulting in the motor and cognitive disorders in the chronic stage is unknown. Using simian immunodeficiency virus-infected rhesus monkeys… CONTINUE READING

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