Host range mutants of vesicular stomatitis virus defective in in vitro RNA methylation.

@article{Horikami1982HostRM,
  title={Host range mutants of vesicular stomatitis virus defective in in vitro RNA methylation.},
  author={S M Horikami and Sue A. Moyer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 24},
  pages={7694-8}
}
The viral RNA polymerase of detergent-treated vesicular stomatitis virus normally synthesizes viral mRNAs in vitro that are both guanylylated and methylated to give 5'-terminal 7mGpppAm caps. We have characterized a virus host range mutant, hr 1, that is totally defective in vitro in the methylation of mRNA, although full-length polyadenylylated mRNAs with 5' termini of the form GpppA are synthesized in normal yields. A second mutant, hr 8, is partially defective in methylation and synthesizes… CONTINUE READING

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