Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner.

@article{Maillard2005HostPA,
  title={Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner.},
  author={Catherine Maillard and Maud Jost and Maria Unni R\omer and Nils Brunner and Xavier Houard and Annabelle Lejeune and Carine Munaut and Khalid Bajou and Laurence Melen and Keld Dano and Peter Carmeliet and Norbert E. Fusenig and Jean Michel Foidart and Agn{\`e}s Noel},
  journal={Neoplasia},
  year={2005},
  volume={7 1},
  pages={57-66}
}
Angiogenesis and tumor expansion are associated with extracellular matrix remodeling and involve various proteases such as the plasminogen (Plg)/plasminogen activator (PA) system. Recently, several experimental data have implicated the plasminogen activator inhibitor-1 (PAI-1) in tumor angiogenesis in murine systems. However, little is known about PAI-1 functions in human skin carcinoma progression. By generating immunodeficient mice (in Rag-1-/- or nude background) deleted for PAI-1 gene (PAI… CONTINUE READING

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