Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

  title={Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses},
  author={Nicolas Simonis and Jean-François Rual and Irma Lemmens and Mathieu Boxus and Tomoko Hirozane-Kishikawa and J S Gatot and Am{\'e}lie Dricot and T. C. Hao and Didier Vertommen and S{\'e}bastien Legros and Sarah Daakour and Niels Klitgord and Maud Martin and Jean-François Willaert and Franck Dequiedt and Vincent Navratil and Michael E. Cusick and Ars{\`e}ne Burny and Carine Van Lint and David E Hill and Jan Tavernier and Richard Kettmann and Marc Vidal and J C Twizere},
Human T-cell leukemia virus type 1 (HTLV-1) and type 2 both target T lymphocytes, yet induce radically different phenotypic outcomes. HTLV-1 is a causative agent of Adult T-cell leukemia (ATL), whereas HTLV-2, highly similar to HTLV-1, causes no known overt disease. HTLV gene products are engaged in a dynamic struggle of activating and antagonistic interactions with host cells. Investigations focused on one or a few genes have identified several human factors interacting with HTLV viral… CONTINUE READING
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