Host-parasite interaction and morbidity in malaria endemic areas.

  title={Host-parasite interaction and morbidity in malaria endemic areas.},
  author={Kevin Marsh and Robert W. Snow},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={352 1359},
Severe morbidity due to Plasmodium falciparum is a major health problem in African children. The patterns of morbidity in endemic areas are modified by the immune response, and vary markedly with transmission intensity. Severe disease falls into three overlapping syndromes: coma, respiratory distress, and severe anaemia. Recently, it has become clear that metabolic acidosis plays a major role in the pathogenesis of severe disease and is particularly important in the overlap between the… CONTINUE READING


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