Host modifier genes affect mouse autoimmunity induced by the lpr gene.

@article{Wang1997HostMG,
  title={Host modifier genes affect mouse autoimmunity induced by the lpr gene.},
  author={Yuhong Wang and Masato Nose and T. O. Kamoto and Mayumi Nishimura and Hiroshi Hiai},
  journal={The American journal of pathology},
  year={1997},
  volume={151 6},
  pages={1791-8}
}
A defect in apoptotic signal transmission through CD95 is an essential genetic mechanism for lymphoproliferation and autoimmunities in lpr or gld mice. However, disease manifestations are largely affected by the host genetic background. To identify and map such host genes modifying lpr gene effect, ie, the lpr modifier (Lprm) genes, 82 MRL/lpr x (MRL/lpr x C3H/lpr) F1 mice were subjected to immunopathological and genetical analyses. High-grade vasculitis and glomerulonephritis among backcross… CONTINUE READING

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