Host-microbe relationships in inflammatory bowel disease detected by bacterial and metaproteomic analysis of the mucosal-luminal interface.

@article{Presley2012HostmicrobeRI,
  title={Host-microbe relationships in inflammatory bowel disease detected by bacterial and metaproteomic analysis of the mucosal-luminal interface.},
  author={Laura L. Presley and Jingxiao Ye and Xiaoxiao Li and James Walter Leblanc and Zhanpan Zhang and Paul M. Ruegger and Jeff Allard and Dermot McGovern and Andrew F. Ippoliti and Bennett E. Roth and Xinping Cui and Daniel R Jeske and David Elashoff and Lee Goodglick and Jonathan Braun and James Borneman},
  journal={Inflammatory bowel diseases},
  year={2012},
  volume={18 3},
  pages={
          409-17
        }
}
BACKGROUND Host-microbe interactions at the intestinal mucosal-luminal interface (MLI) are critical factors in the biology of inflammatory bowel disease (IBD). METHODS To address this issue, we performed a series of investigations integrating analysis of the bacteria and metaproteome at the MLI of Crohn's disease, ulcerative colitis, and healthy human subjects. After quantifying these variables in mucosal specimens from a first sample set, we searched for bacteria exhibiting strong… CONTINUE READING

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