Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death.

@article{Detweiler2001HostMA,
  title={Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death.},
  author={Corrella S Detweiler and Dolores Cunanan and Stanley Falkow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 10},
  pages={5850-5}
}
Bacterial pathogens manipulate host cells to promote pathogen survival and dissemination. We used a 22,571 human cDNA microarray to identify host pathways that are affected by the Salmonella enterica subspecies typhimurium phoP gene, a transcription factor required for virulence, by comparing the expression profiles of human monocytic tissue culture cells infected with either the wild-type bacteria or a phoPTn10 mutant strain. Both wild-type and phoPTn10 bacteria induced a common set of genes… CONTINUE READING

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