Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum.

@article{Clark2014HostIS,
  title={Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum.},
  author={M. Clark and M. Goheen and A. Fulford and A. Prentice and Marwa Elnagheeb and J. Patel and N. Fisher and Steve M Taylor and R. Kasthuri and C. Cerami},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={
          4446
        }
}
Iron deficiency and malaria have similar global distributions, and frequently co-exist in pregnant women and young children. Where both conditions are prevalent, iron supplementation is complicated by observations that iron deficiency anaemia protects against falciparum malaria, and that iron supplements increase susceptibility to clinically significant malaria, but the mechanisms remain obscure. Here, using an in vitro parasite culture system with erythrocytes from iron-deficient and replete… Expand
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  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2019
TLDR
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References

SHOWING 1-10 OF 48 REFERENCES
Iron deficiency influences the course of malaria in Plasmodium berghei infected mice.
TLDR
In conclusion, iron deficiency favourably influences the course of malaria, an effect partially due to accelerated suicidal death and subsequent clearance of infected erythrocytes. Expand
Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency.
TLDR
Interventional trials of iron and folate supplementation during pregnancy in malaria-endemic regions in Africa are urgently needed to ascertain the benefits and risks of this intervention. Expand
Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children.
  • M. Gwamaka, J. Kurtis, +5 authors P. Duffy
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2012
TLDR
Malaria risk is influenced by physiologic iron status, and therefore iron supplementation may have adverse effects even among children with ID, and future interventional studies should assess whether treatment for ID coupled with effective malaria control can mitigate the risks of iron supplementation for children in areas of malaria transmission. Expand
Reduced risk for placental malaria in iron deficient women
TLDR
Iron deficiency was less frequent in women with placental Plasmodium falciparum infection than women without placental malaria infection and the association was greater in multigravidae. Expand
Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stage Plasmodium falciparum
TLDR
The method for detecting the LIP within malaria parasitized RBCs provides evidence that the parasite is able to access serum iron sources as part of the host vs. parasite arms race for iron. Expand
Iron deficiency and malaria among children living on the coast of Kenya.
TLDR
It is concluded that iron deficiency was associated with protection from mild clinical malaria in a cohort of children in coastal Kenya and possible mechanisms for this protection are discussed. Expand
A critical role for phagocytosis in resistance to malaria in iron‐deficient mice
TLDR
The results of this study suggest that parasitized IDA erythrocytes are eliminated by phagocytic cells, which sense alterations in the membrane structure of parasitized Ida ery Throatcytes. Expand
Low red cell production may protect against severe anemia during a malaria infection--insights from modeling.
The malaria parasite causes lysis of red blood cells, resulting in anemia, a major cause of mortality and morbidity. Intuitively, one would expect the production of red blood cells to increase inExpand
Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism.
TLDR
It is determined that Lipocalin 2 (Lcn2), a host protein that sequesters iron, is abundantly secreted during human and mouse blood-stage malaria infections and is essential to control P. yoeliiNL parasitemia, anemia, and host survival. Expand
Iron delocalisation in the pathogenesis of malarial anaemia.
TLDR
It is proposed that cytokine- and hepcidin-mediated iron delocalisation, a principal mechanism in the anaemia of inflammation, plays an important role in the aetiology of malarial anaemia, and can explain some of the clinical and laboratory findings. Expand
...
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