Host innate immune receptors and beyond: making sense of microbial infections.

@article{Ishii2008HostII,
  title={Host innate immune receptors and beyond: making sense of microbial infections.},
  author={Ken J Ishii and Syohei Koyama and Atsushi Nakagawa and Cevayir Coban and Shizuo Akira},
  journal={Cell host & microbe},
  year={2008},
  volume={3 6},
  pages={352-63}
}
The complexity of the immune system mirrors its manifold mechanisms of host-microbe interactions. A relatively simplified view was posited after the identification of host innate immune receptors that their distinct mechanisms of sensing "microbial signatures" create unique molecular switches to trigger the immune system. Recently, more sophisticated and cooperative strategies for these receptors have been revealed during receptor-ligand interactions, trafficking, and intra- and intercellular… CONTINUE READING
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