Host immune system gene targeting by a viral miRNA.

@article{SternGinossar2007HostIS,
  title={Host immune system gene targeting by a viral miRNA.},
  author={Noam Stern-Ginossar and Naama Elefant and Albert Zimmermann and Dana G. Wolf and Nivin Saleh and Moshe Biton and Elad Horwitz and Zafnat Prokocimer and M. H. Prichard and Gabriele G. Hahn and Debra Goldman-Wohl and Caryn Greenfield and Simcha Yagel and Hartmut Hengel and Yael Altuvia and Hanah Margalit and Ofer Mandelboim},
  journal={Science},
  year={2007},
  volume={317 5836},
  pages={
          376-81
        }
}
Virally encoded microRNAs (miRNAs) have recently been discovered in herpesviruses. However, their biological roles are mostly unknown. We developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompatibility complex class I-related chain B (MICB) gene as a top candidate target of hcmv-miR-UL112. MICB is a stress-induced ligand of the natural killer (NK) cell activating receptor NKG2D and is… CONTINUE READING
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